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1. Hong  WR, Hong  WR, Ge  M, Zeng  ZH, Zhu  L, Luo  MY, Shao  L, Chen  DJ,     ( 2009 )

Molecular cloning and sequence analysis of the sisomicin biosynthetic gene cluster from Micromonospora inyoensis.

Biotechnology letters 31 (3)
PMID : 19039528  :   DOI  :   10.1007/s10529-008-9887-y    
Abstract >>
Micromonospora inyoensis produces sisomicin (Sm), an aminoglycoside antibiotic. The gene cluster of sisomicin biosynthesis spanning ca. 47 kb consists of 37 ORFs encoding various proteins for sisomicin biosynthesis, regulation, resistance and transport. The comparative genetic studies on the biosynthetic genes of sisomicin and gentamicin (Gm) reveal a similar biosynthetic route and provide a framework for the future biosynthetic studies.
KeywordMeSH Terms
Biosynthetic Pathways
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