| decarbamoylnovobiocin carbamoyltransferase |
| Name : | Decarbamoylnovobiocin carbamoyltransferase (EC 2.1.3.12) (Novobiocin biosynthesis protein N) |
| Reaction : | decarbamoylnovobiocin + carbamoyl phosphate <--> novobiocin + phosphate |
|
UNIPROT ID :
Q9L9F4
BioCyc ID:
MONOMER-18052
|
|
| demethyldecarbamoyl novobiocin O-methyltransferase |
| Name : | Demethyldecarbamoylnovobiocin O-methyltransferase (EC 2.1.1.285) (Novobiocin biosynthesis protein P) |
| Reaction : | S-adenosyl-L-methionine + demethyldecarbamoyl novobiocin <--> S-adenosyl-L-homocysteine + decarbamoylnovobiocin + H+ |
|
UNIPROT ID :
Q9L9F2
BioCyc ID:
MONOMER-18053
|
|
| 4-O-demethyl-L-noviosyl transferase |
| Name : | L-demethylnoviosyl transferase (EC 2.4.1.302) (Novobiocin biosynthesis protein M) |
| Reaction : | novobiocic acid + dTDP-4-O-demethyl-beta-L-noviose <--> demethyldecarbamoyl novobiocin + dTDP + H+ |
|
UNIPROT ID :
Q9L9F5
BioCyc ID:
MONOMER-18054
|
|
| 8-demethylnovobiocic acid C8-methyltransferase |
| Name : | 8-demethylnovobiocic acid C(8)-methyltransferase (EC 2.1.1.284) (Novobiocin biosynthesis protein O) |
| Reaction : | S-adenosyl-L-methionine + 8-demethylnovobiocic acid <--> S-adenosyl-L-homocysteine + novobiocic acid + H+ |
|
UNIPROT ID :
Q9L9F3
BioCyc ID:
MONOMER-18055
|
|
| 8-demethylnovobiocate synthase |
| Name : | 8-demethylnovobiocic acid synthase (EC 6.3.1.15) (8-demethylnovobiocic acid synthetase) (Novobiocic acid synthetase) (Novobiocin biosynthesis protein L) (Novobiocin ligase) |
| Reaction : | 3-amino-4,7-dihydroxy-coumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP <--> 8-demethylnovobiocic acid + AMP + diphosphate + H+ |
|
UNIPROT ID :
Q9L9F6
BioCyc ID:
MONOMER-18056
|
|
| β-hydroxy-L-tyrosine-[NovH] dehydrogenase |
| Name : | Short-chain reductase protein NovJ (EC 1.1.1.-) (Novobiocin biosynthesis protein J) |
| Reaction : | (R)-beta-hydroxy-L-tyrosine-S-[NovH protein] + NADP+ <--> beta-oxo-L-tyrosine-S-[NovH protein] + NADPH + H+ |
|
UNIPROT ID :
Q9L9F8
BioCyc ID:
MONOMER-18082
|
|
| β-hydroxy-L-tyrosine-[NovH] dehydrogenase |
| Name : | Short-chain dehydrogenase/reductase family member NovK (Novobiocin biosynthesis protein K) |
| Reaction : | (R)-beta-hydroxy-L-tyrosine-S-[NovH protein] + NADP+ <--> beta-oxo-L-tyrosine-S-[NovH protein] + NADPH + H+ |
|
UNIPROT ID :
Q9L9F7
BioCyc ID:
MONOMER-18083
|
|
| NovH peptidyl-carrier protein |
| Name : | Novobiocin biosynthesis protein H (EC 6.-.-.-) |
| Reaction : | a NovH peptidyl-carrier protein + L-tyrosine + ATP <--> L-tyrosine-S-[NovH protein] + AMP + diphosphate |
|
UNIPROT ID :
Q9L9G0
BioCyc ID:
MONOMER-18084
|
|
| L-tyrosine-[NovH-protein] β-hydroxylase |
| Name : | Cytochrome P450 NovI (EC 1.14.-.-) (Novobiocin biosynthesis protein I) |
| Reaction : | L-tyrosine-S-[NovH protein] + NADPH + oxygen + H+ <--> (R)-beta-hydroxy-L-tyrosine-S-[NovH protein] + NADP+ + H2O |
|
UNIPROT ID :
Q9L9F9
BioCyc ID:
MONOMER-18085
|
|
| glucose-1-phosphate thymidylyltransferase |
| Name : | Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) (Novobiocin biosynthesis protein V) (dTDP-glucose pyrophosphorylase) (dTDP-glucose synthase) |
| Reaction : | dTTP + alpha-D-glucopyranose 1-phosphate + H+ <--> dTDP-alpha-D-glucose + diphosphate |
|
UNIPROT ID :
Q9L9E6
BioCyc ID:
MONOMER-18086
|
|
| dTDP-glucose 4,6-dehydratase |
| Name : | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) (Novobiocin biosynthesis protein T) |
| Reaction : | dTDP-alpha-D-glucose <--> dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + H2O |
|
UNIPROT ID :
Q9L9E8
BioCyc ID:
MONOMER-18087
|
|
| dTDP-4-dehydro-6-deoxy-α-D-glucose 3,5-epimerase |
| Name : | dTDP-4-dehydrorhamnose 3-epimerase (EC 5.1.3.-) (Novobiocin biosynthesis protein W) (dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase) |
| Reaction : | dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose <--> dTDP-4-dehydro-beta-L-rhamnose |
|
UNIPROT ID :
Q9L9E5
BioCyc ID:
MONOMER-18088
|
|
| dTDP-4-dehydro-β-L-rhamnose C5-methyltransferase |
| Name : | C-methyltransferase NovU (EC 2.1.1.-) (Novobiocin biosynthesis protein U) |
| Reaction : | S-adenosyl-L-methionine + dTDP-4-dehydro-beta-L-rhamnose <--> dTDP-4-dehydro-5-methyl-beta-L-rhamnose + S-adenosyl-L-homocysteine + H+ |
|
UNIPROT ID :
Q9L9E7
BioCyc ID:
MONOMER-18089
|
|
| dTDP-4-dehydro-5-methyl-L-rhamnose 4-ketoreductase |
| Name : | dTDP-4-keto-6-deoxy-D-glucose reductase (EC 1.1.1.-) (Novobiocin biosynthesis protein S) |
| Reaction : | dTDP-4-O-demethyl-beta-L-noviose + NAD+ <--> dTDP-4-dehydro-5-methyl-beta-L-rhamnose + NADH + H+ |
|
UNIPROT ID :
Q9L9E9
BioCyc ID:
MONOMER-18090
|
|
| 4-hydroxyphenylpyruvate dimethylallyl transferase |
| Name : | 4-hydroxyphenylpyruvate 3-dimethylallyltransferase (EC 2.5.1.111) (4HPP 3-dimethylallyltransferase) (Aromatic prenyltransferase NovQ) (Dimethylallyl diphosphate:4-hydroxyphenylpyruvate dimethylallyl transferase) (Novobiocin biosynthesis protein Q) |
| Reaction : | prenyl diphosphate + 3-(4-hydroxyphenyl)pyruvate <--> 3-dimethylallyl-4-hydroxyphenylpyruvate + diphosphate |
|
UNIPROT ID :
Q9L9F1
BioCyc ID:
MONOMER-18091
|
|
| prephenate dehydrogenase |
| Name : | Probable prephenate dehydrogenase NovF (EC 1.3.1.12) (Novobiocin biosynthesis protein F) |
| Reaction : | prephenate + NAD+ <--> 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH |
|
UNIPROT ID :
Q9L9G2
BioCyc ID:
MONOMER-18092
|
|
| 3-dimethylallyl-4-hydroxyphenylpyruvate oxygenase |
| Name : | Decarboxylase NovR (EC 4.1.-.-) (Novobiocin biosynthesis protein R) |
| Reaction : | 3-dimethylallyl-4-hydroxyphenylpyruvate + oxygen <--> 3-dimethylallyl-4-hydroxymandelate + CO2 |
|
UNIPROT ID :
Q9L9F0
BioCyc ID:
MONOMER-18093
|
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