L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase |
Name : | L-glutamine:2-deoxy-scyllo-inosose aminotransferase (L-glutamine:DOI aminotransferase) (EC 2.6.1.100) (Bifunctional L-glutamine:ketocyclitol aminotransferase I/II) (L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase) (L-glutamine:amino-DOI aminotransferase) (EC 2.6.1.101) |
Reaction : | L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose <--> 2-oxoglutaramate + 2-deoxystreptamine |
UNIPROT ID :
Q53U20
BioCyc ID:
MONOMER-17227
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2-deoxy-scyllo-inosose synthase |
Name : | 2-deoxy-scyllo-inosose synthase (DOI synthase) (DOIS) (EC 4.2.3.124) |
Reaction : | D-glucopyranose 6-phosphate <--> 2-deoxy-L-scyllo-inosose + phosphate |
UNIPROT ID :
Q53U19
BioCyc ID:
MONOMER-17230
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2-deoxy-scyllo-inosamine dehydrogenase |
Name : | 2-deoxy-scyllo-inosamine dehydrogenase (DOIA dehydrogenase) (EC 1.1.1.329) |
Reaction : | 2-deoxy-scyllo-inosamine + NAD(P)+ <--> 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+ |
UNIPROT ID :
Q53U21
BioCyc ID:
MONOMER-17231
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6'''-hydroxyneomycin C 6'-oxidase |
Name : | Paromamine 6'-oxidase (EC 1.1.3.43) (6'''-hydroxyneomycin C oxidase) (EC 1.1.3.44) (Neomycin biosynthesis protein 11) (Neo-11) (Neomycin biosynthesis protein Q) |
Reaction : | 6'''-deamino-6'''-hydroxyneomycin C + oxygen <--> 6'''-deamino-6'''-oxoneomycin C + hydrogen peroxide |
UNIPROT ID :
Q53U15
BioCyc ID:
MONOMER-17237
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glutamate--6'-dehydroparomanine aminotransferase |
Name : | Neamine transaminase NeoN (EC 2.6.1.93) (Glutamate--6'-dehydroparomamine aminotransferase) (Neomycin C transaminase) (EC 2.6.1.95) (Neomycin biosynthesis protein 18) (Neo-18) (Neomycin biosynthesis protein B) (Neomycin biosynthesis protein N) |
Reaction : | neamine + 2-oxoglutarate <--> 6'-dehydroparomamine + L-glutamate |
UNIPROT ID :
Q53U08
BioCyc ID:
MONOMER-17238
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2'-N-acetylparomamine deacetylase |
Name : | 2'-N-acetylparomamine deacetylase (EC 3.5.1.112) (2'''-acetyl-6'''-hydroxyneomycin C deacetylase) (EC 3.5.1.113) (Neomycin biosynthesis protein 16) (Neo-16) (Neomycin biosynthesis protein L) |
Reaction : | 2'-N-acetylparomamine + H2O <--> paromamine + acetate |
UNIPROT ID :
Q53U10
BioCyc ID:
MONOMER-17259
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2-deoxystreptamine N-acetyl-D-glucosaminyltransferase |
Name : | 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase (EC 2.4.1.283) (Neomycin biosynthesis protein 8) (Neo-8) (Neomycin biosynthesis protein D) |
Reaction : | UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine <--> 2'-N-acetylparomamine + UDP + H+ |
UNIPROT ID :
Q53U18
BioCyc ID:
MONOMER-17260
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UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase |
Name : | UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase (EC 2.4.1.285) (Neomycin biosynthesis protein 15) (Neo-15) (Neomycin biosynthesis protein K) |
Reaction : | UDP-N-acetyl-alpha-D-glucosamine + ribostamycin <--> 2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + UDP + H+ |
UNIPROT ID :
Q53U11
BioCyc ID:
MONOMER-17261
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neamine phosphoribosyltransferase |
Name : | Putative ribosyltransferase |
Reaction : | neamine + 5-phospho-alpha-D-ribose 1-diphosphate <--> 5''-phosphoribostamycin + diphosphate |
UNIPROT ID :
Q53U09
BioCyc ID:
MONOMER-17281
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5''-phosphoribostamycin phosphatase |
Name : | Putative phosphatase in neomycin pathway, NeoP (Putative phosphomutase) |
Reaction : | 5''-phosphoribostamycin + H2O <--> ribostamycin + phosphate |
UNIPROT ID :
Q53U13
BioCyc ID:
MONOMER-17282
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tylactone synthase |
Name : | Tylactone synthase starter module and modules 1 & 2 |
Reaction : | 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O |
UNIPROT ID :
O33954
BioCyc ID:
MONOMER-18375
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tylactone synthase |
Name : | Tylactone synthase module 3 |
Reaction : | 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O |
UNIPROT ID :
O33955
BioCyc ID:
MONOMER-18376
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tylactone synthase |
Name : | Tylactone synthase modules 4 & 5 |
Reaction : | 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O |
UNIPROT ID :
O33956
BioCyc ID:
MONOMER-18377
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tylactone synthase |
Name : | Tylactone synthase module 6 |
Reaction : | 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O |
UNIPROT ID :
O33957
BioCyc ID:
MONOMER-18378
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tylactone synthase |
Name : | Tylactone synthase module 7 |
Reaction : | 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O |
UNIPROT ID :
O33958
BioCyc ID:
MONOMER-18379
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tylactone mycaminosyltransferase |
Name : | Tylactone mycaminosyltransferase (EC 2.4.1.316) |
Reaction : | tylactone + dTDP-alpha-D-mycaminose <--> 5-O-beta-mycaminosyltylactone + dTDP + H+ |
UNIPROT ID :
P95747
BioCyc ID:
MONOMER-18380
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dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose N,N-dimethyltransferase |
Name : | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (EC 2.1.1.235) (Tylosin biosynthesis protein M1) |
Reaction : | 2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose <--> 2 S-adenosyl-L-homocysteine + dTDP-alpha-D-mycaminose + 2 H+ |
UNIPROT ID :
P95748
BioCyc ID:
MONOMER-18381
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dTDP-glucose 4,6-dehydratase |
Name : | dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) |
Reaction : | dTDP-alpha-D-glucose <--> dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + H2O |
UNIPROT ID :
Q54144
BioCyc ID:
MONOMER-18382
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glucose-1-phosphate thymidylyltransferase |
Name : | Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) |
Reaction : | dTTP + alpha-D-glucopyranose 1-phosphate + H+ <--> dTDP-alpha-D-glucose + diphosphate |
UNIPROT ID :
Q54143
BioCyc ID:
MONOMER-18383
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dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose transaminase |
Name : | Uncharacterized protein |
Reaction : | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate <--> dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate |
UNIPROT ID :
Q54142
BioCyc ID:
MONOMER-18384
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5-O-mycaminosyltylactone C20-hydroxylase |
Name : | Cytochrome P-450 |
Reaction : | 5-O-beta-mycaminosyltylactone + 2 a reduced ferredoxin [iron-sulfur] cluster + oxygen + 2 H+ <--> 20-hydroxy-5-O-mycaminosyltylactone + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O |
UNIPROT ID :
Q59910
BioCyc ID:
MONOMER-18388
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20-oxo-5-O-mycaminosyltylactone 23-monooxygenase |
Name : | 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase (EC 1.14.15.34) (Cytochrome P-450 monooxygenase TylH1) |
Reaction : | 20-oxo-5-O-beta-mycaminosyltylactone + 2 a reduced ferredoxin [iron-sulfur] cluster + oxygen + 2 H+ <--> 5-O-beta-mycaminosyltylonolide + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O |
UNIPROT ID :
Q9ZHQ1
BioCyc ID:
MONOMER-18389
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O-mycaminosyltylonolide 6-deoxyallosyltransferase |
Name : | O-mycaminosyltylonolide 6-deoxyallosyltransferase (EC 2.4.1.317) |
Reaction : | 5-O-beta-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <--> demethyllactenocin + dTDP + H+ |
UNIPROT ID :
O70023
BioCyc ID:
MONOMER-18390
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demethyllactenocin mycarosyltransferase |
Name : | Demethyllactenocin mycarosyltransferase (EC 2.4.1.318) |
Reaction : | demethyllactenocin + dTDP-beta-L-mycarose <--> demethylmacrocin + dTDP + H+ |
UNIPROT ID :
Q9XC67
BioCyc ID:
MONOMER-18391
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demethylmacrocin O-methyltransferase |
Name : | Demethylmacrocin O-methyltransferase (EC 2.1.1.102) (Tylosin biosynthesis protein E) |
Reaction : | S-adenosyl-L-methionine + demethylmacrocin <--> S-adenosyl-L-homocysteine + macrocin + H+ |
UNIPROT ID :
Q9ZHQ4
BioCyc ID:
MONOMER-18392
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macrocin O-methyltransferase |
Name : | Macrocin O-methyltransferase (MacOMeTase) (EC 2.1.1.101) (Tylosin biosynthesis protein F) |
Reaction : | S-adenosyl-L-methionine + macrocin <--> tylosin + S-adenosyl-L-homocysteine + H+ |
UNIPROT ID :
Q9S4D5
BioCyc ID:
MONOMER-18393
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tylactone thioesterase |
Name : | Thioesterase |
Reaction : | 2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O |
UNIPROT ID :
Q54145
BioCyc ID:
MONOMER-18394
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tylactone mycaminosyltransferase |
Name : | Protein TylM3 |
Reaction : | tylactone + dTDP-alpha-D-mycaminose <--> 5-O-beta-mycaminosyltylactone + dTDP + H+ |
UNIPROT ID :
P95746
BioCyc ID:
MONOMER-18409
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