| pyruvate carboxylase |
| Name : | Pyruvate carboxylase (EC 6.4.1.1) (Pyruvic carboxylase) (PCB) |
| Reaction : | pyruvate + hydrogencarbonate + ATP <--> oxaloacetate + ADP + phosphate + H+ |
|
UNIPROT ID :
O93918
BioCyc ID:
MONOMER-13631
|
|
| cis-aconitate decarboxylase |
| Name : | Cis-aconitate decarboxylase (CAD) (EC 4.1.1.6) (Aconitate decarboxylase) (Cis-aconitic acid decarboxylase) |
| Reaction : | cis-aconitate + H+ <--> CO2 + itaconate |
|
UNIPROT ID :
B3IUN8
BioCyc ID:
MONOMER-13632
|
|
| aconitase |
| Name : | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.-) |
| Reaction : | citrate <--> cis-aconitate + H2O |
|
UNIPROT ID :
O74699
BioCyc ID:
MONOMER-13634
|
|
| lovastatin nonaketide synthase |
| Name : | Lovastatin nonaketide synthase, enoyl reductase component (EC 2.3.1.161) |
| Reaction : | S-adenosyl-L-methionine + 9 malonyl-CoA + lovastatin nonaketide synthase + 11 NADPH + 19 H+ <--> dihydromonacolin L-[lovastatin nonaketide synthase] + S-adenosyl-L-homocysteine + 9 CO2 + 9 coenzyme A + 11 NADP+ + 6 H2O |
|
UNIPROT ID :
Q9Y7D0
BioCyc ID:
MONOMER-18781
|
|
| lovastatin nonaketide synthase |
| Name : | Lovastatin nonaketide synthase, polyketide synthase component (LNKS) (EC 2.3.1.161) |
| Reaction : | S-adenosyl-L-methionine + 9 malonyl-CoA + lovastatin nonaketide synthase + 11 NADPH + 19 H+ <--> dihydromonacolin L-[lovastatin nonaketide synthase] + S-adenosyl-L-homocysteine + 9 CO2 + 9 coenzyme A + 11 NADP+ + 6 H2O |
|
UNIPROT ID :
Q9Y8A5
BioCyc ID:
MONOMER-18782
|
|
| monacolin L hydroxylase |
| Name : | Dihydromonacolin L monooxygenase LovA (EC 1.14.14.124) (EC 1.14.14.125) (Dihydromonacolin L hydroxylase) (Monacolin L hydroxylase) |
| Reaction : | monacolin L acid + a reduced [NADPH-hemoprotein reductase] + oxygen <--> monacolin J acid + an oxidized [NADPH-hemoprotein reductase] + H2O |
|
UNIPROT ID :
Q9Y7C8
BioCyc ID:
MONOMER-18784
|
|
| monacolin J acid methylbutanoate transferase |
| Name : | Monacolin J acid methylbutanoyltransferase (EC 2.3.1.238) (Lovastatin hydrolase) (Simvastatin synthase LovD) (SV synthase) |
| Reaction : | monacolin J acid + (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] <--> lovastatin acid + a holo-2-methylbutanoyl-[polyketide synthase] |
|
UNIPROT ID :
Q9Y7D1
BioCyc ID:
MONOMER-18785
|
|
| 2-methylbutanoate polyketide synthase |
| Name : | Lovastatin diketide synthase LovF (LDKS) (EC 2.3.1.244) |
| Reaction : | S-adenosyl-L-methionine + 2 malonyl-CoA + a holo-2-methylbutanoyl-[polyketide synthase] + 2 NADPH + 3 H+ <--> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + S-adenosyl-L-homocysteine + 2 CO2 + 2 coenzyme A + 2 NADP+ + H2O |
|
UNIPROT ID :
Q9Y7D5
BioCyc ID:
MONOMER-18789
|
|
