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The information shown in this page was generated using the cross-referenced linkage within public domain database between their strains and BCRC related strains. Usually the information provided from public domain databases varies with different confidences and errors, BCRC provides the related information here at best effort, but BCRC doesn't take the responsibility about the correctness of the information provided here.
L-glutamine:5-amino-2,3,4-trihydroxycyclohexanone aminotransferase
Name :L-glutamine:2-deoxy-scyllo-inosose aminotransferase (L-glutamine:DOI aminotransferase) (EC 2.6.1.100) (Bifunctional L-glutamine:ketocyclitol aminotransferase I/II) (L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase) (L-glutamine:amino-DOI aminotransferase) (EC 2.6.1.101)
Reaction :L-glutamine + 3-amino-2,3-dideoxy-scyllo-inosose <--> 2-oxoglutaramate + 2-deoxystreptamine
UNIPROT ID : Q53U20      BioCyc ID: MONOMER-17227
2-deoxy-scyllo-inosose synthase
Name :2-deoxy-scyllo-inosose synthase (DOI synthase) (DOIS) (EC 4.2.3.124)
Reaction :D-glucopyranose 6-phosphate <--> 2-deoxy-L-scyllo-inosose + phosphate
UNIPROT ID : Q53U19      BioCyc ID: MONOMER-17230
2-deoxy-scyllo-inosamine dehydrogenase
Name :2-deoxy-scyllo-inosamine dehydrogenase (DOIA dehydrogenase) (EC 1.1.1.329)
Reaction :2-deoxy-scyllo-inosamine + NAD(P)+ <--> 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+
UNIPROT ID : Q53U21      BioCyc ID: MONOMER-17231
6'''-hydroxyneomycin C 6'-oxidase
Name :Paromamine 6'-oxidase (EC 1.1.3.43) (6'''-hydroxyneomycin C oxidase) (EC 1.1.3.44) (Neomycin biosynthesis protein 11) (Neo-11) (Neomycin biosynthesis protein Q)
Reaction :6'''-deamino-6'''-hydroxyneomycin C + oxygen <--> 6'''-deamino-6'''-oxoneomycin C + hydrogen peroxide
UNIPROT ID : Q53U15      BioCyc ID: MONOMER-17237
glutamate--6'-dehydroparomanine aminotransferase
Name :Neamine transaminase NeoN (EC 2.6.1.93) (Glutamate--6'-dehydroparomamine aminotransferase) (Neomycin C transaminase) (EC 2.6.1.95) (Neomycin biosynthesis protein 18) (Neo-18) (Neomycin biosynthesis protein B) (Neomycin biosynthesis protein N)
Reaction :neamine + 2-oxoglutarate <--> 6'-dehydroparomamine + L-glutamate
UNIPROT ID : Q53U08      BioCyc ID: MONOMER-17238
2'-N-acetylparomamine deacetylase
Name :2'-N-acetylparomamine deacetylase (EC 3.5.1.112) (2'''-acetyl-6'''-hydroxyneomycin C deacetylase) (EC 3.5.1.113) (Neomycin biosynthesis protein 16) (Neo-16) (Neomycin biosynthesis protein L)
Reaction :2'-N-acetylparomamine + H2O <--> paromamine + acetate
UNIPROT ID : Q53U10      BioCyc ID: MONOMER-17259
2-deoxystreptamine N-acetyl-D-glucosaminyltransferase
Name :2-deoxystreptamine N-acetyl-D-glucosaminyltransferase (EC 2.4.1.283) (Neomycin biosynthesis protein 8) (Neo-8) (Neomycin biosynthesis protein D)
Reaction :UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine <--> 2'-N-acetylparomamine + UDP + H+
UNIPROT ID : Q53U18      BioCyc ID: MONOMER-17260
UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase
Name :UDP-GlcNAc:ribostamycin N-acetylglucosaminyltransferase (EC 2.4.1.285) (Neomycin biosynthesis protein 15) (Neo-15) (Neomycin biosynthesis protein K)
Reaction :UDP-N-acetyl-alpha-D-glucosamine + ribostamycin <--> 2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + UDP + H+
UNIPROT ID : Q53U11      BioCyc ID: MONOMER-17261
neamine phosphoribosyltransferase
Name :Putative ribosyltransferase
Reaction :neamine + 5-phospho-alpha-D-ribose 1-diphosphate <--> 5''-phosphoribostamycin + diphosphate
UNIPROT ID : Q53U09      BioCyc ID: MONOMER-17281
5''-phosphoribostamycin phosphatase
Name :Putative phosphatase in neomycin pathway, NeoP (Putative phosphomutase)
Reaction :5''-phosphoribostamycin + H2O <--> ribostamycin + phosphate
UNIPROT ID : Q53U13      BioCyc ID: MONOMER-17282
tylactone synthase
Name :Tylactone synthase starter module and modules 1 & 2
Reaction :2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O
UNIPROT ID : O33954      BioCyc ID: MONOMER-18375
tylactone synthase
Name :Tylactone synthase module 3
Reaction :2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O
UNIPROT ID : O33955      BioCyc ID: MONOMER-18376
tylactone synthase
Name :Tylactone synthase modules 4 & 5
Reaction :2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O
UNIPROT ID : O33956      BioCyc ID: MONOMER-18377
tylactone synthase
Name :Tylactone synthase module 6
Reaction :2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O
UNIPROT ID : O33957      BioCyc ID: MONOMER-18378
tylactone synthase
Name :Tylactone synthase module 7
Reaction :2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O
UNIPROT ID : O33958      BioCyc ID: MONOMER-18379
tylactone mycaminosyltransferase
Name :Tylactone mycaminosyltransferase (EC 2.4.1.316)
Reaction :tylactone + dTDP-alpha-D-mycaminose <--> 5-O-beta-mycaminosyltylactone + dTDP + H+
UNIPROT ID : P95747      BioCyc ID: MONOMER-18380
dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose N,N-dimethyltransferase
Name :dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (EC 2.1.1.235) (Tylosin biosynthesis protein M1)
Reaction :2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose <--> 2 S-adenosyl-L-homocysteine + dTDP-alpha-D-mycaminose + 2 H+
UNIPROT ID : P95748      BioCyc ID: MONOMER-18381
dTDP-glucose 4,6-dehydratase
Name :dTDP-glucose 4,6-dehydratase (EC 4.2.1.46)
Reaction :dTDP-alpha-D-glucose <--> dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose + H2O
UNIPROT ID : Q54144      BioCyc ID: MONOMER-18382
glucose-1-phosphate thymidylyltransferase
Name :Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24)
Reaction :dTTP + alpha-D-glucopyranose 1-phosphate + H+ <--> dTDP-alpha-D-glucose + diphosphate
UNIPROT ID : Q54143      BioCyc ID: MONOMER-18383
dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose transaminase
Name :Uncharacterized protein
Reaction :dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate <--> dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
UNIPROT ID : Q54142      BioCyc ID: MONOMER-18384
5-O-mycaminosyltylactone C20-hydroxylase
Name :Cytochrome P-450
Reaction :5-O-beta-mycaminosyltylactone + 2 a reduced ferredoxin [iron-sulfur] cluster + oxygen + 2 H+ <--> 20-hydroxy-5-O-mycaminosyltylactone + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O
UNIPROT ID : Q59910      BioCyc ID: MONOMER-18388
20-oxo-5-O-mycaminosyltylactone 23-monooxygenase
Name :20-oxo-5-O-mycaminosyltylactone 23-monooxygenase (EC 1.14.15.34) (Cytochrome P-450 monooxygenase TylH1)
Reaction :20-oxo-5-O-beta-mycaminosyltylactone + 2 a reduced ferredoxin [iron-sulfur] cluster + oxygen + 2 H+ <--> 5-O-beta-mycaminosyltylonolide + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O
UNIPROT ID : Q9ZHQ1      BioCyc ID: MONOMER-18389
O-mycaminosyltylonolide 6-deoxyallosyltransferase
Name :O-mycaminosyltylonolide 6-deoxyallosyltransferase (EC 2.4.1.317)
Reaction :5-O-beta-mycaminosyltylonolide + dTDP-6-deoxy-alpha-D-allose <--> demethyllactenocin + dTDP + H+
UNIPROT ID : O70023      BioCyc ID: MONOMER-18390
demethyllactenocin mycarosyltransferase
Name :Demethyllactenocin mycarosyltransferase (EC 2.4.1.318)
Reaction :demethyllactenocin + dTDP-beta-L-mycarose <--> demethylmacrocin + dTDP + H+
UNIPROT ID : Q9XC67      BioCyc ID: MONOMER-18391
demethylmacrocin O-methyltransferase
Name :Demethylmacrocin O-methyltransferase (EC 2.1.1.102) (Tylosin biosynthesis protein E)
Reaction :S-adenosyl-L-methionine + demethylmacrocin <--> S-adenosyl-L-homocysteine + macrocin + H+
UNIPROT ID : Q9ZHQ4      BioCyc ID: MONOMER-18392
macrocin O-methyltransferase
Name :Macrocin O-methyltransferase (MacOMeTase) (EC 2.1.1.101) (Tylosin biosynthesis protein F)
Reaction :S-adenosyl-L-methionine + macrocin <--> tylosin + S-adenosyl-L-homocysteine + H+
UNIPROT ID : Q9S4D5      BioCyc ID: MONOMER-18393
tylactone thioesterase
Name :Thioesterase
Reaction :2 malonyl-CoA + 5 (S)-methylmalonyl-CoA + (2S)-ethylmalonyl-CoA + 7 NADPH + 15 H+ <--> tylactone + 8 CO2 + 8 coenzyme A + 7 NADP+ + 3 H2O
UNIPROT ID : Q54145      BioCyc ID: MONOMER-18394
tylactone mycaminosyltransferase
Name :Protein TylM3
Reaction :tylactone + dTDP-alpha-D-mycaminose <--> 5-O-beta-mycaminosyltylactone + dTDP + H+
UNIPROT ID : P95746      BioCyc ID: MONOMER-18409

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